Speaker: David Saylor, FDA
Title: Microstructure-Based Modeling of Controlled Drug Release Coatings

Abstract: In recent years, controlled drug release coatings, comprising drug in a polymer matrix, have been integrated with medical devices to improve functionality and performance. While it has been demonstrated that the internal structure of these composites significantly alters drug release, the impact of materials selection and manufacturing conditions on microstructure development during processing and the subsequent release kinetics is not well established. Therefore, we have developed a diffuse interface model for microstructure evolution in these coatings. Calculations based on the model are used to predict microstructural changes during both manufacturing and use. These computations, which are consistent with experimental observations, have been used to establish relations between processing, microstructure, and drug release kinetics. These relations provide a means to rapidly assess new products and processing routes, evaluate the suitability of process specifications, and guide product design.

Time: Friday, April 18, 2008, 1:30-2:30 p.m.

Place: Research I, Room 301

Department of Mathematical Sciences
George Mason University
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